TECHNOLOGY


KINAXO Cellular Target Profiling®
Determine your compound’s proteome-wide interactions		     KinAffinity™
Evaluate your kinase inhibitor’s target spectrum on a kinome-wide basis		     PhosphoScout™
Gain insights into your compound’s cellular mode of action		  
KINAXO Cellular Target Profiling® determines a small molecules’ quantitative cellular target profile
  • Profile any small molecule in any cell line or tissue of choice
  • Determine proteome-wide target affinities
  • Examine your compound’s selectivity
  • Identify novel targets and potential off-target liabilities
  KINAXO’s KinAffinity™ rapidly and efficiently profiles kinase inhibitors against any cell line or tissue
  • Profile kinase inhibitors against endogenously expressed kinases in a physiological context
  • Determine kinase binding affinities across a native kinome
  • Identify novel kinase targets not detectable by kinase panel screening
  KINAXO’s quantitative phosphoproteomics technology comprehensively investigates drug effects at the signal transduction level
  • Quantify regulated phos-
    phorylation sites in living cells, animal models and patient samples and map them to relevant signal transduction pathways
  • Identify new biomarkers and drug targets
  • Depict the cellular mode of action of your targeted drug
  • Reduce development times and predict therapeutic outcome
 
     Applications:
  • Lead optimization
  • Target deconvolution
  • Drug re-profiling
  • Clinical candidate selection
     Applications:
  • Kinase inhibitor selectivity analysis
  • Lead compound optimization
  • Clinical candidate selection
     Applications:
  • Target validation and identification
  • Mode of action analysis
  • Biomarker identification
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